Table 2.
Relative frequency of HIV-1 replication inhibition by >90% in R5 viruses (n = 29)
| Conc. | CMPD-167, % | BMS-C, % | T-1249, % | CMPD + BMS-C, % | CMPD + T-1249, % | BMS-C + T-1249, % | Triple combination, % |
|---|---|---|---|---|---|---|---|
| Low* | 0 | 10 | 0 | 14 | 3 | 17 | 21 |
| High† | 52 | 41 | 41 | 86 | 100 | 76 | 100 |
| Top‡ | 100 | 72 | 100 | 100 | 100 | 100 | 100 |
*CMPD-167, 0.1 nM; all others, 1 nM, alone and in combinations.
†CMPD-167, 1 nM; all others, 10 nM, alone and in combinations.
‡CMPD-167, 100 nM; all others, 1 μM, alone and in combinations.