Table 4.

Relative frequency of HIV-1 replication inhibition by >90% in R5X4 viruses (n = 7)

Conc.	AMD3465, %	CMPD-167, %	AMD + CMPD-167, %	BMS-C, %	T-1249, %	CoR* + BMS-C, %	CoR + T-1249, %	BMS-C + T-1249, %	Quadruple combination, %
Low†	0	0	0	29	0	29	14	43	71
High‡	29	14	43	86	0	100	100	100	100
Top§	71	14	100	100	100	100	100	100	100

*CoR, mixture of AMD3465 with CMPD167.

^†AMD3465, 5 nM; CMPD-167, 0.1 nM; all others, 1 nM, alone and in combinations.

^‡AMD3465, 50 nM; CMPD-167, 1 nM; all others, 10 nM, alone and in combinations.

^§AMD3465, 5 μM; CMPD-167, 100 nM; all others, 1 μM, alone and in combinations. At this high concentration of AMD3465, nonspecific effects on R5 virus infection were also seen.