Table 5.

T-1249 and T-20 activities in the PhenoSense assay against HIV-1 Env-pseudotyped viruses derived from plasmas of treatment-naïve individuals

Tropism	T-1249 IC50, nM*	T-20 IC50, nM*
R5 (n = 393)†	9.1 (12)	55 (110)
X4 (n = 22)	17 (16)	120 (140)
Dual-tropic‡ (R5X4/R5 + X4) (n = 221)	5.1 (6.9)	33 (66)
Dual-tropic on CCR5+ cells§	6.3 (7.5)	34 (61)
Dual-tropic on CXCR4+ cells§	4.2 (15)	32 (160)

*The half-maximal inhibitory concentrations (IC₅₀) are given as geometric means with the upward standard deviation shown in parentheses.

^†n denotes the number of pseudotyped viruses tested.

^‡Some dual-tropic viruses can use both CCR5 and CXCR4 for entry (R5X4), others may constitute a mixture of R5 viruses and X4 viruses (R5 + X4).

^§The dual-tropic viruses were tested both on U87-CD4/CCR5 cells and on U87-CD4/CXCR4 cells.