Fig. 3.

MCH-deficient mice develop attenuated TNBS-induced acute colitis. (A) Histological scoring of inflammation in H&E-stained colonic cross-sections from TNBS-treated MCH ^−/− mice and their WT littermates. (Calibration bar = 400 μm.) (B) Colonic expression of various proinflammatory cytokines at 48 h post-TNBS exposure was measured in MCH ^−/− and MCH ^+/+ mice by real-time PCR. (C) Colonic MCH expression at 48 h post-TNBS in WT mice was measured by real-time PCR. *, p < 0.05 compared to control.