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After 28 d of treatment with GSI plus Qa, PrPSc levels remain low for 21 d after treatment is ceased. (A) Western immunoblots of PrPSc in the cortex and thalamus from three mice each at 50, 78, 99, and 106 dpi are shown (85 and 92 dpi; data not shown). (B and C) Estimates of PrPSc concentrations (n = 3 mice) in the cortex (B) and thalamus (C) are given. Relative PrPSc levels from infected DMSO mice at 78, 85, 92, and 99 dpi were estimated by using data from an earlier study.
