Table 1.

 Example of Framework charting for data management in main study

Patient ID	Sex	Age (years)	Cancer site	Clinician ID	Treatment decision	Quotes from oncologist
						Purpose of treatment	Survival benefit discussion
301	M	65	Lung	101	Chemotherapy offered and accepted	It’s a relatively uncommon situation and normally if you can’t do an operation then there’s very little chance of curing a lung cancer I’m afraid (cont…)	If we can’t achieve that, a cure, then we’re looking to control it, shrink it, get rid of the cough, buy time. In this situation I think it’s a bit more unclear (cont…)
302	F	57	Pancreas	102	Chemotherapy offered and accepted	Now none of the drugs that have been developed are cures and they don’t work for everybody. About 30% of people who receive them (cont …)	You’ve got to be fit for it. Now with chemotherapy, the benefit is not seen at all in the people who would do very badly anyway, right (cont…)
303	F	69	Colorectal	103	Chemotherapy offered and accepted	Now the situation is that chemotherapy has its pros and its cons. The problem is that when the cancer is widespread like this, treatment is what we call palliative (cont…)	The aim of chemotherapy therefore is to keep you going, not just to give you extra quantity of life but extra quality of life. The evidence is that people who respond to treatment, they get both (cont…)