Table 1.

Inhibition of cathepsins K, B, L, and S by compounds 4–7

Ki, app, nM		kobs/[I], m−1s−1
Compound	Cat K	Cat K	Cat B	Cat L	Cat S
4	0.7	3.1  ×  106	1.3  ×  103	5.8  ×  104	Ki = 11 nM
5	>1,000	2.2  ×  103	Ki > 5,000 nM	Ki > 5,000 nM	Ki > 1,000 nM
6	1.0	6.9  ×  105	3.4  ×  103	3.8  ×  103	Ki = 44 nM
7	—	5.3  ×  106	1.4  ×  103	1.2  ×  105	Ki = 24 nM