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. 2008 Apr 5;79(3):492–499. doi: 10.1093/cvr/cvn088

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

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Aortic valve calcification in diet group rat. (A) En-face view of open aortic valve showing diffuse calcification of valve's annulus and commisures (black arrows). (B) Cross-section through the aortic sinus showing coarse calcification of aortic valve annulus (arrows) with normal appearing leaflets (haematoxylin & eosin, original magnification ×25). (C) Higher magnification of calcified annulus (Von Kossa, original magnification ×50). (D) Focal cartilaginous metaplasia of aortic valve annulus (haematoxylin & eosin, original magnification ×200). (E) Focal subendothelial macrophage aggregate (large arrow) and myxoid degeneration of leaflet (small arrow) (haematoxylin & eosin, original magnification ×400).

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