Table 1.

Biochemical profiles of the study groups

	Diet (high phosphate)			Control	Low phosphate
	Week 4 (n = 15)	Week 9 (n = 15)	Week 19 (n = 8)‡	Week 9 (n = 10)	Week 4 (n = 10)
Creatinine (mmol/L)	213 ± 3.78*	90 ± 1.47	80 ± 2.7	70 ± 3.6	207 ± 2.58
Phosphate (mmol/L)	4.20 ± 0.06*	2.62 ± 0.03	1.6 ± 0.02	2.5 ± 0.03	2.2 ± 0.06**
PTH (pg/mL)	2800 ± 40†	750 ± 123†	414 ± 37	281 ± 53	210 ± 40**
Total cholesterol (mmol/L)	3.14 ± 0.01	2.83 ± 0.03	—	2.1 ± 0.04	—
Alkaline phosphatase (U/L)	189 ± 6.33	173 ± 2.33	—	189 ± 1.2	—
Potassium (mmol/L)	5.92 ± 0.02	4.93 ± 0.07	—	5.8 ± 0.09	—

Biochemical profile obtained from three groups. In the diet group: at 4 weeks (during the adenine diet), at 9 weeks (2 weeks after cessation of diet), and at 19 weeks (the reversibility subgroup). In the low-phosphate group at 4 weeks and the control group at 9 weeks. At 4 weeks there was significant increase in creatinine, phosphate, and parathyroid hormone (PTH) levels in the diet group blood compared with the control; creatinine was similar to the low-phosphate group, while the phosphate and PTH were significantly higher. After 9 weeks, creatinine and phosphate level in the diet group decreased, while the PTH levels were still significantly higher than the controls. After 19 weeks, creatinine, phosphate, and PTH levels were normalized.

*P < 0.05 for the comparison of diet group with the control group.

^†P < 0.01 for the comparison of diet group with the control group.

**P < 0.05 for the comparison of diet group with the low-phosphate group.

^‡The reversibility subgroup.