Table 2.
Actin sliding speed, M5/N6 | Actin–tropomyosin sliding speed, M5/N6 | Actin–tropomyosin–troponin sliding speed at pCa5, M5/N6 | Actin–tropomyosin–troponin sliding speed at pCa9, M5/N6 | Actin–tropomyosin–troponin fraction motile at pCa9, M5/N6 | |
---|---|---|---|---|---|
Preparation 1 | 1.28 | 1.21 | 1.46 | 1.52 | 2.78 |
Preparation 2 | 1.44 | 1.18 | 1.43 | 1.32 | 1.01 |
Preparation 3 | 1.60 | 1.24 | 1.22 | 1.12 | 1.77 |
Comparison of motility parameters of non-failing heart myosin (N6) and HOCM myosin, M5. M5 has a consistently hypercontractile molecular phenotype.