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Enzymes that have been treated with chymotrypsin to reveal an increase in activity at pH 8.5 also have an altered response to their allosteric effectors. A and B demonstrate the response of the uncleaved (filled circles) and cleaved (open circles) enzyme to GTP with (A) NAD+ and (B) NADP+ as the cofactor. (C,D) Results for the same enzyme samples assayed for ADP response with NAD+ and NADP+, respectively.
