Table 2.
"Global functional analysis" conducted using Ingenuity Pathway Analysis.
| Time after transfection | siRNA | Category | Process Annotation | Significance |
| 18 h | TP53 | Cell Death | cell death of tumor cell lines | 5.96E-09 |
| Organismal Survival | survival of mammalia | 9.59E-09 | ||
| Cell Death | cell death of lung cancer cell lines | 3.72E-08 | ||
| Organismal Survival | survival of mice | 9.84E-08 | ||
| Cellular Growth and Proliferation | colony formation of eukaryotic cells | 1.48E-07 | ||
| LSR1 | Cancer | proliferation of tumor cell lines | 3.78E-07 | |
| DNA Replication, Recombination, and Repair | synthesis of DNA | 4.61E-07 | ||
| Cell Death | apoptosis of cell lines | 1.67E-06 | ||
| Cancer | cell death of tumor cell lines | 1.95E-06 | ||
| Organismal Survival | survival of mammalia | 2.29E-06 | ||
| LSR2 | Cancer | growth of tumor cell lines | 2.11E-07 | |
| Cellular Growth and Proliferation | growth of cell lines | 3.14E-07 | ||
| Cancer | proliferation of tumor cell lines | 1.38E-06 | ||
| Cardiovascular System Development and Function | development of blood vessel | 1.78E-06 | ||
| Cellular Growth and Proliferation | growth of eukaryotic cells | 2.85E-06 | ||
| TP53+LSR1 | Cellular Growth and Proliferation | colony formation of eukaryotic cells | 5.07E-10 | |
| Organismal Survival | survival of mammalia | 8.79E-09 | ||
| Cellular Growth and Proliferation | colony formation of cell lines | 1.11E-08 | ||
| Cell Death | cell death of cell lines | 3.66E-08 | ||
| Cancer | colony formation of tumor cell lines | 1.11E-07 | ||
| 48 h | TP53 | Cell-To-Cell Signaling and Interaction | activation of eukaryotic cells | 1.17E-10 |
| Organismal Survival | survival of rodents | 1.74E-09 | ||
| Cellular Growth and Proliferation | proliferation of cell lines | 1.29E-08 | ||
| Cellular Growth and Proliferation | growth of central nervous system cells | 1.76E-08 | ||
| Cellular Growth and Proliferation | colony formation of cells | 3.72E-08 | ||
| LSR1 | Cellular Movement | cell movement | 3.26E-12 | |
| Cellular Movement | invasion of eukaryotic cells | 2.31E-11 | ||
| Cellular Movement | invasion of cell lines | 1.61E-09 | ||
| Cellular Movement | cell movement of cell lines | 3.84E-09 | ||
| Cellular Movement | cell movement of endothelial cells | 4.24E-09 | ||
| LSR2 | Cellular Movement | cell movement | 2.72E-15 | |
| Cellular Growth and Proliferation | growth of tumor cell lines | 4.45E-12 | ||
| Cellular Movement | cell movement of eukaryotic cells | 4.54E-12 | ||
| Cell-To-Cell Signaling and Interaction | adhesion of cells | 4.78E-12 | ||
| Cellular Movement | cell movement of cell lines | 7.54E-12 | ||
| TP53+LSR1 | Renal and Urological Disease | renal and urological disorder of rodents | 3.87E-08 | |
| Renal and Urological Disease | renal and urological disorder of rats | 1.05E-07 | ||
| Cancer | growth of tumor cell lines | 1.99E-07 | ||
| Cellular Growth and Proliferation | colony formation of eukaryotic cells | 5.94E-07 | ||
| Cellular Growth and Proliferation | colony formation of cell lines | 1.18E-06 | ||
| 72 h | TP53 | Tissue Development | development of tissue | 5.91E-08 |
| Tissue Development | angiogenesis of chorioallantoic membrane | 8.76E-08 | ||
| Renal and Urological Disease | renal and urological disorder of rodents | 1.01E-07 | ||
| Cancer | angiogenesis of tumor | 1.82E-07 | ||
| Cellular Movement | cell movement | 1.99E-07 | ||
| LSR1 | Cellular Movement | cell movement | 8.99E-11 | |
| Cellular Movement | migration of eukaryotic cells | 2.41E-09 | ||
| Cellular Movement | cell movement of eukaryotic cells | 2.46E-09 | ||
| Cellular Movement | cell movement of cell lines | 5.27E-09 | ||
| Cellular Movement | migration of tumor cell lines | 1.72E-08 | ||
| LSR2 | Cellular Movement | cell movement | 5.60E-15 | |
| Cellular Movement | cell movement of eukaryotic cells | 2.46E-13 | ||
| Cellular Movement | migration of eukaryotic cells | 7.57E-13 | ||
| Cellular Growth and Proliferation | growth of tumor cell lines | 5.66E-12 | ||
| Tissue Development | formation of tissue | 8.77E-12 | ||
| TP53+LSR1 | Cellular Movement | migration of eukaryotic cells | 4.19E-10 | |
| Cellular Movement | cell movement | 8.74E-10 | ||
| Cellular Movement | cell movement of eukaryotic cells | 1.57E-09 | ||
| Cancer | angiogenesis of tumor | 6.86E-09 | ||
| Renal and Urological Disease | renal and urological disorder of rodents | 8.15E-09 | ||
The list includes the annotation of the differentially expressed genes upon knockdown. The likelihood that the association between a set of differentially expressed genes and a given function was due to chance was calculated using the right-tailed Fisher's exact test. The biological functions or processes annotated to affected genes are listed according to their significance.