Table 4.
Comparison of ciclosporin (CsA) trough blood concentration of different genotypes and haplotypes under the same regimen
| Ciclosporin regimen | 50 mg twice daily | 50 mg three times daily | 100 mg twice daily | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype of MDR1 C1236T | CC (1) | CT (22) | TT (16) | CC (8) | CT (22) | TT (25) | CC (6) | CT (25) | TT (41) |
| C0 | 36.70 | 94.34 ± 73.63 | 58.92 ± 42.11 | 72.27 ± 30.98 | 112.6 ± 72.93 | 90.42 ± 56.49 | 95.35 ± 32.03 | 118.9 ± 46.58 | 142.0 ± 46.40 |
| Genotype of MDR1 G2677T | CC (10) | CT (23) | TT (6) | CC (19) | CT (24) | TT (12) | CC (18) | CT (38) | TT (17) |
| C0 | 102.3 ± 79.77 | 72.50 ± 60.31 | 60.43 ± 39.27 | 97.47 ± 65.19 | 82.87 ± 56.44 | 122.9 ± 63.03 | 133.8 ± 76.06 | 137.6 ± 54.13 | 156.6 ± 46.51 |
| Genotype of MDR1 C3435T | CC (13) | CT (21) | TT (9) | CC (23) | CT (24) | TT (9) | CC (21) | CT (36) | TT (19) |
| C0 | 78.84 ± 77.25 | 83.02 ± 63.77 | 75.37 ± 49.80 | 121.5 ± 72.70 | 92.11 ± 56.67 | 121.5 ± 72.50 | 134.8 ± 71.13 | 144.4 ± 54.88 | 138.2 ± 51.49 |
| MDR1 haplotype | CC-GG-CC (8) | CT-GT-CT (11) | TT-TT-TT (9) | CC-GG-CC (4) | CT-GT-CT (14) | TT-TT-TT (13) | |||
| C0 | 72.27 ± 30.98 | 112.27 ± 68.25 | 121.5 ± 72.70 | 88.51 ± 34.57 | 146 ± 67.48 | 147.4 ± 20.60 | |||
Values are given as arithmetic mean ± SD. The number in parentheses indicates the number of patients. C0, CsA trough concentrations in ng ml−1.