Table 4.
Four haplotypes and nine genotypes of MDR1deduced from single nucleotide polymorphism (SNP) C1236T (exon 12) and C3435T (exon 26)
| Genotype | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 00 | 01 | 02 | 10 | 11 | 12 | 20 | 21 | 22 | ||||||||||
| Pos 1236 | T | T | T | T | T | T | C | T | C | T | C | T | C | C | C | C | C | C |
| Pos 3435 | C | C | C | T | T | T | C | C | C | T | T | T | C | C | C | T | T | T |
| Haplotype | 11 | 11 | 11 | 12 | 12 | 12 | 21 | 11 | 21 | 12 | 22 | 12 | 21 | 21 | 21 | 22 | 22 | 22 |
| or | ||||||||||||||||||
| Pos 1236 | C | T | ||||||||||||||||
| Pos 3435 | T | C | ||||||||||||||||
| Haplotype | 22 | 11 | ||||||||||||||||
| n | 1 | 4 | 4 | 6 | 6 | 0 | 3 | 0 | 0 | |||||||||
Genotype coding: 0, homozygous for nucleotides identical with the reference sequence (1236TT, 3435CC); 1, heterozygous (1236CT, 3435CT); 2, homozygous for nucleotides different from the reference sequence (1236CC, 3435TT). The first digit refers to the exon 12 SNP, and the second refers to the exon 26. Haplotype coding is a follow: 1, identical to the reference sequence (variant in exon 12, 1236T, variant in exon 26, 3435C); 2, different from the reference sequence (variant in exon 12, 1236C, variant in exon 26, 3435T).