Table 5.
Comparison of pharmacokinetic parameters after a single oral administration of valacyclovir between groups with different linked genotype at positions 2677 vs. 3435 and 1236 vs. 3435 of MDR1 gene
| Cmax (µg ml−1) | AUC0–1.5 h (µg × h/ml) | AUC0–∞ (µg × h/ml) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Combined genotype | n | Mean ± SD | 95% CI of differences | Mean ± SD | 95% CI of differences | Mean ± SD | 95% CI of differences | ||
| 2677 vs.3435 | GG | CC | 3 | 2.96 ± 0.37 | 2.81 ± 0.60 | 10.44 ± 1.00* | |||
| AA | CC | 1 | 1.78 | – | 1.51 | – | 9.50 | – | |
| GA | CC | 4 | 3.92 ± 1.07 | (−1.34, 3.27) | 3.20 ± 1.12 | (−1.73, 2.50) | 11.84 ± 2.83* | (−.3.63, 6.42) | |
| GT | CC | 2 | 3.67 ± 0.10 | – | 3.04 ± 1.08 | – | 15.14 ± 1.27 | – | |
| GT | CT | 7 | 3.92 ± 2.04 | (−1.12, 3.05) | 3.43 ± 1.70 | (−1.29, 2.53) | 12.64 ± 4.09* | (−2.34, 6.74) | |
| TA | CT | 3 | 4.46 ± 1.10 | (−0.95, 3.97) | 3.99 ± 1.36 | (−1.08, 3.44) | 17.45 ± 2.40 | (1.64, 12.37) | |
| TT | TT | 4 | 2.92 ± 0.67 | (−2.34, 2.27) | 2.46 ± 0.74 | (−2.46, 1.77) | 11.34 ± 2.32* | (−4.13, 5.92) | |
| 1236 vs. 3435 | CC | CC | 3 | 2.86 ± 1.44 | 2.41 ± 1.51 | 10.98 ± 3.35** | |||
| CT | CC | 6 | 3.56 ± 0.76 | (−1.25, 2.63) | 2.96 ± 0.62 | (−1.18, 2.27) | 11.58 ± 1.90** | (−3.80, 4.99) | |
| CT | CT | 6 | 4.70 ± 1.92 | (−0.11, 3.78) | 4.22 ± 1.77 | (0.08, 3.53) | 16.07 ± 4.09 | (0.69, 9.48) | |
| TT | CC | 1 | 3.75 | – | 3.80 | – | 16.04 | – | |
| TT | CT | 4 | 3.17 ± 1.15 | (−1.79, 2.40) | 2.67 ± 0.38 | (−1.60, 2.12) | 11.10 ± 2.41** | (−4.63, 4.86) | |
| TT | TT | 4 | 2.92 ± 0.67 | (−2.05, 2.15) | 2.46 ± 0.74 | (−1.81, 1.91) | 11.34 ± 2.32** | (−4.40, 5.10) | |
95%CI of differences, compared with 2677GG/3435CC group, 1236CC/3435CC group. Data are expressed as arithmetic mean ± standard deviation (SD).
*Statistically significant difference (P < 0.05) compared with 2677TA/3435CT group.
**Statistically significant difference (P < 0.05) compared with 1236CT/3435CT group.