Table 6.
Comparisons of valacyclovir pharmacokinetic parameters between subjects grouped according to MDR1 haplotype 11, 12 and 21 deduced from single nucleotide polymorphism C1236T and C3435T
| Cmax (µg ml−1) | AUC0–1.5 h (µg × h/ml) | AUC0–∞ (µg × h/ml) | ||||
|---|---|---|---|---|---|---|
| Mean ± SD | 95% CI of differences | Mean ± SD | 95% CI of differences | Mean ± SD | 95% CI of differences | |
| Haplotype 11 | ||||||
| Carrier (n = 11) | 3.43 ± 0.86 | 2.93 ± 0.58 | 11.81 ± 2.36 | |||
| Noncarrier (n = 13) | 3.73 ± 1.69 | (−1.46, 0.88) | 3.26 ± 1.63 | (−1.41, 0.75) | 13.44 ± 4.08 | (−4.53, 1.26) |
| Haplotype 12 | ||||||
| Carrier (n = 14) | 3.75 ± 1.60 | 3.27 ± 1.44 | 13.30 ± 3.90 | |||
| Noncarrier (n = 10) | 3.37 ± 0.95 | (−0.79, 1.56) | 2.88 ± 0.94 | (−0.69, 1.48) | 11.85 ± 2.60 | (−1.49, 4.40) |
| Haplotype 21 | ||||||
| Carrier (n = 15) | 3.87 ± 1.54 | 3.35 ± 1.47 | 13.26 ± 3.82 | |||
| Noncarrier (n = 9) | 3.12 ± 0.86 | (−0.41, 1.92) | 2.71 ± 0.66 | (−0.43, 1.73) | 11.75 ± 2.61 | (−1.49, 4.50) |
Carriers are endowed with at least one respective haplotype. Data are means ± SD. Mann–Whitney test was used for comparisons within haplotype groups.