Figure 1.

(a) Changes in absolute blood flow (ml min⁻¹ per 100 ml of forearm volume) in the infused arm in response to acetylcholine (Ach) infusion (6 and 20 µg min⁻¹) before and after atropine. Data are mean ± SEM. P < 0.001 ACh vs. ACh plus atropine. (b) Changes in absolute blood flow (ml min⁻¹ per 100 ml of forearm volume) in the infused arm in response to ACh infusion (0.6, 2, 6, 20 and 60 µg min⁻¹) after a 1-week period of treatment with darifenacin compared with placebo. Data are mean ± SEM. P < 0.001 darifenacin vs. placebo