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Mechanisms of repression of the interleukin-4 gene IL-4. T-bet acts to silence IL-4 expression in T helper type 1 cells via recruitment of the histone methyl transferase EZH2. Interferon regulatory factor 1 has been described as a repressor of IL-4 transcription that binds to the IL-4 promoter. miR-155 is a microRNA that is thought to inhibit translation of c-Maf RNA.
