Figure 3.

Organization of the interleukin-4 (IL-4)/IL-5/IL-13 locus. Horizontal arrows indicate the position and direction of transcription of genes. CpG islands are indicated by downward-pointing vertical arrows and the numbers of CpG dinucleotides within each cluster are stated. Location of binding sites for transcription factors demonstrated by chromatin immunoprecipitation in T helper type 1 (Th1) and Th2 cells are shown. The positions of DNase I hypersensitive sites in Th2 cells are shown by upward-pointing vertical arrows. The known regulatory regions, CNS-1 and CNS-2, are also indicated.