Table 1. Gene ontology list for target sequences used in PAINT analysis.
| Gene Ontology | Gene name | Cluster | Gene Ontology | Gene name | Cluster |
|---|---|---|---|---|---|
| |
|
|
Growth factor binding |
IGFBP-1 |
Undifferentiated |
| Cell cycle effectors |
CDC25A |
Undifferentiated |
|
IGFBP-3 |
Undifferentiated |
| |
Cyclin H |
Undifferentiated |
|
EMAP II |
Undifferentiated |
| |
Cdc2-related protein kinase |
Undifferentiated |
|
IL-13 |
Undifferentiated |
| |
G(1)/G(S)/G(2) beta2 |
Undifferentiated |
|
||
| |
|
|
Cell death |
Caspase 4 |
Undifferentiated |
| Cell adhesion |
I-CAM-1 |
Undifferentiated |
|
ICE LAP3 |
Undifferentiated |
| |
V-CAM-1 |
Undifferentiated |
|
||
| |
E-selectin |
Undifferentiated |
Cell organization |
alpha-SMA |
Undifferentiated |
| |
Integrin alpha4 |
Undifferentiated |
|
ZO1 |
Differentiated |
| |
Integrin beta5 |
Undifferentiated |
|
Thymosin beta10 |
Differentiated |
| |
N-cadherin |
Undifferentiated |
|
||
| |
Fibronectin |
Differentiated |
Signal transduction |
STK-2 |
Undifferentiated |
| |
CD44 antigen |
Differentiated |
|
CAK |
Undifferentiated |
| |
Integrin alpha5 |
Differentiated |
|
MAPK3 |
Undifferentiated |
| |
Integrin beta4 |
Differentiated |
|
PDGF-B |
Undifferentiated |
| |
R-cadherin |
Differentiated |
|
CD33 antigen |
Undifferentiated |
| |
|
|
|
RGS19IP1 |
Undifferentiated |
| Cell metabolism |
CLK-1 |
Undifferentiated |
|
FADK2 |
Undifferentiated |
| |
STK-1 |
Undifferentiated |
|
Tyk2 |
Undifferentiated |
| |
Tyrosinase |
Differentiated |
|
RAB5A |
Undifferentiated |
| |
PEDF |
Differentiated |
|
PKCgamma17 |
Undifferentiated |
| |
RPE65 |
Differentiated |
|
IGF-1 |
Undifferentiated |
| |
TYRP2 |
Differentiated |
|
VEGF |
Undifferentiated |
| |
|
|
|
MCP-1 |
Undifferentiated |
| Ion binding |
CAM IV |
Undifferentiated |
|
Neuromodulin |
Undifferentiated |
| |
SPARC/Osteonectin |
Differentiated |
|
FADK2 |
Undifferentiated |
| |
|
|
|
PAK-C alpha |
Undifferentiated |
| Transcription factors |
CRE BP-1 |
Undifferentiated |
FGFR-1 |
Differentiated |
|
| |
TFAP 2 |
Undifferentiated |
FGFR-3 |
Differentiated |
|
| |
|
|
|
HDGF |
Differentiated |
| Proliferation/differentiation |
STAT6 |
Undifferentiated |
|||
| |
GDF-1 |
Undifferentiated |
Inter/intra cellular transport |
MAL |
Undifferentiated |
| |
|
|
|
MCT-4 |
Undifferentiated |
| |
|
|
|
MCT-3 |
Differentiated |
| Bestrophin | Differentiated |
The three columns indicate the gene name, gene ontology cluster assignment, and inclusion into either the differentiated or undifferentiated retinal pigment epithelium expression cluster. The genes were organized within the ontology clusters according to The Gene Ontology Consortium (2000).