Table 1. MS identification of protein species induced by yca1 ablation.
Spot | Name | Score/peptides | Notes a |
C1 | PST2 | 72/2 | Mitochondrial; Oxidative stress response protein induced by YAP1 |
C3 | MRP8 | 52/2 | Putative mitochondrial ribosomal protein |
C4 | PUP2 | 73/3 | Alpha subunit of 20S proteasome |
C5 | LIA1 | 171/5 | deoxyhypusine hydroxylase; Possible role in mitochondrial positioning |
C6 | SGT2 | 151/5 | Similarity to human SGT which negatively regulates HSP70 |
C7 | PEP4 | 155/4 | Aspartate protease involved in metabolic degradation (pepsin like); important for protein turnover after oxidative damage |
C8 | TIF2 | 347/9 | eIF4a homolog |
C10 | PYK1 | 90/5 | Pyruvate kinase |
C11 | RAD23 | 181/4 | Nucleotide excision repair; DNA damage checkpoint role normally degraded during G1/S transition |
C12 | PDI1 | 227/7 | Protein disulfide isomerase involved in formation and management of scrambled protein disulfide bonds |
Notes derived from ORF descriptions available at www.yeastgenome.org.