Table 1. Therapeutic targets in the innate immune response to MTb, and their effect on adaptive immune outcomes.
| # | Therapeutic Targets | Approach | Expected innate response | Possible adaptive response | References |
|---|---|---|---|---|---|
| 1 |
TLR 2
(+1 or 6) |
Agonist | Strong IL-10
Weak IL 12p70 |
Th2 | 31,32 |
| 2 | TLR 4 | Agonist | Strong IL-12p70
IFN α |
Th1 | 31, 32, 45 |
| 3 | TLR 9 | Agonist | Strong IFN α
Strong IL-12p70 |
Th1 | 31, 32, 33 |
| 4 | NOD2 | Agonist | IL-23 | Th17 | 35 |
| 5 | DC-SIGN | Agonist | IL-10 | Th2/Th0 | 34 |
| 6 | Dectin-1 | Agonist | IL-12p40 | ? Th1 | 13, 14 |