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. 2008 May 21;84(2):371–379. doi: 10.1189/jlb.1207847

Fig. 4.

Fig. 4.

Vγ2 cells differ in expression of CD27 and CD45RA between HIV+ and control donors before and after IPP stimulation. PBMC from HIV+ (n=24) and control (n=9) donors were stained with Vγ2, CD27, and CD45RA antibodies before and after stimulation with 100 U IL-2, IL-2 and 15 μM IPP, or IL-2 and 0.25 μg/ml PHA. Shown are representative plots for HIV+ and control donors on Day 00 and after 14 days in culture post-15 μM IPP stimulation. The average frequency of CD27–/CD45RA– Vγ2 cells is higher among control donors than HIV+ donors after IPP stimulation (78.4±10.3 vs. 47.4±25.2, respectively; P<0.001). Conversely, CD27–/CD45RA+ Vγ2 cells are more frequent after IPP stimulation among HIV+ donors than controls (20.1±19.4 vs. 1.1±0.7, respectively; P<0.005). Similar trends were observed after stimulation with IL-2 alone. P values are results of Student’s t-tests.