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. 2008 Jul;21(3):466–472. doi: 10.1128/CMR.00059-07

TABLE 2.

Numbers of travelers needed to take chemoprophylaxis to prevent one case of malaria and to prevent one fatal case of malaria at different levels of endemicity

Annual incidence of cases of malaria in local population No. of travelers needed
Taking prophylaxis to prevent 1 casea Taking prophylaxis to prevent 1 deatha,b With severe side effects to prevent 1 malaria casec With severe side effects to prevent 1 deathc
1 per 1,000 26,000 1,300,000 2,600 130,000
10 per 1,000 2,600 130,000 260 13,000
20 per 1,000 1,300 65,000 130 6,500
50 per 1,000 520 26,000 52 2,600
100 per 1,000 260 13,000 26 1,300
a

Assuming 2 weeks of travel.

b

Assuming 2% mortality.

c

Severe side effects in 10% of cases.