TABLE 4.
Antimalarial chemoprophylaxis for children
| Antimalarial | Indication for chemoprophylaxis | Dosing | Description |
|---|---|---|---|
| Atovaquone-proguanil | >5 kg body wt per CDCa | Daily | Palatable |
| >11 kg body wt per manufacturer and some European countries | Pediatric tablets | Expensive | |
| Chloroquine (hydroxychloroquine) | All ages and weights | 5 mg base/kg weekly | Limited use due to resistance |
| Proguanil | All ages and weights | 3 mg/kg/day | Only in combination with chloroquine |
| Doxycycline | Children >8 yr old | 1.5 mg salt/kg daily | Contraindicated for small children |
| Mefloquine | Children >5 kg | 5 mg/kg weekly | Bitter taste |
| Primaquine | Children >4 yr old per WHO | 0.5 mg/kg base | G6PD testing essential |
| CDC specifies no lower age limit | Daily | Last choice |
a
New recommendations for 2007.