TABLE 5.
Pharmacokinetic parametersa of PNU-286607 (QPT-1) in plasma from mice
| Treatment route | Dose (mg/kg) | t1/2 (h) | Tmax (hr) | Cmax (μg/ml) | AUC0-∞ (μg·hr/ml) | CL (liter/kg/h) | Vss (liter/kg) | F (%) |
|---|---|---|---|---|---|---|---|---|
| Intravenous | 21.6 | 1.22 | 15.7 | 31 | 0.697 | 0.623 | ||
| Oral | 20.3 | 0.927 | 1 | 15.7 | 27.6 | 94.7 |
a
AUC0-∞ area under the plasma drug concentration-time curve from 0 h to infinity; Cmax, maximum concentration observed in plasma; CL, plasma clearance; F, oral bioavailability; Tmax, time at which the maximum concentration in plasma was first observed; t1/2, elimination half-life; Vss, volume of distribution at steady state.