TABLE 2.

Antibiotic susceptibility distributions of 14 antimicrobials against 197 isolates of H. influenzae^a

Antibiotic	MIC (μg/ml)						Pb	Geometric mean
	MIC50		MIC90		Range
	1997	2007	1997	2007	1997	2007		1997	2007	% Variation
Amoxicillin	1	0.5	≥64	32	≤0.25-≥64	≤0.25-≥64	0.05	2.83	1.67	-41.0
Amoxicillin-clavulanic acid	0.5	0.5	2	2	0.25-4	0.25-4	0.49	0.78	0.84	+7.69
Cefaclor	4	4	16	16	1-32	≤0.5-32	0.003	5.23	4.43	-15.30
Cefuroxime	1	1	4	4	0.25-8	0.25-8	0.07	1.16	1.07	-7.76
Cefotaxime	≤0.01	≤0.01	0.06	0.06	≤0.01-0.12	≤0.01-0.25	0.94	0.18	0.18	0.00
Cefixime	≤0.06	≤0.06	≤0.06	≤0.06	≤0.06-0.5	≤0.06-0.25	0.66	0.063	0.062	-1.59
Cefpodoxime	≤0.06	≤0.06	0.25	0.25	≤0.06-0.25	≤0.06-0.5	0.85	0.084	0.086	+2.38
Chloramphenicol	≤0.5	≤0.5	1	≤0.5	≤0.5-8	≤0.5-8	0.008	0.63	0.54	-14.29
Tetracycline	≤0.5	≤0.5	≤0.5	≤0.5	≤0.5-≥8	≤0.5-4	0.14	0.55	0.51	-7.27
Telithromycin	≥2	≥2	≥2	≥2	0.5-≥2	0.5-≥2	0.19	1.72	1.73	+0.58
Clarithromycin	8	8	16	16	2-32	2-16	0.65	9.15	8.91	-2.62
Azithromycin	2	2	4	4	0.25-8	0.5-8	0.0001	1.60	2.19	+36.88
Trimethoprim-Sulfamethoxazole	1	≤0.25	16	16	≤0.25-≥64	≤0.25-32	0.03	1.69	0.97	-42.60
Ciprofloxacin	≤0.03	≤0.03	≤0.03	≤0.03

^aSignificant values are indicated in boldface.

^bAs determined by an unpaired t test.