TABLE 1.
Characteristics of the 11 qnrS1-positive study isolates
| Isolate | PFGE type | Hospitala | Ward | Specimen | Date of isolation (mo/day/yr) | Ciprofloxacin MICb (μg/ml) | Mutation(s) detected in:
|
Antibiotic(s) to which isolate exhibited phenotypic resistanceb,c | |
|---|---|---|---|---|---|---|---|---|---|
| gyrA | parC | ||||||||
| 1 | I | A | Outpatient | Urine | 3/7/07 | 32 | S83L, D87N | S80R | AMP |
| 2 | II | B | Medical | Urine | 2/8/06 | 32 | S83L, D87N | S80I, E84V | AMP |
| 3 | III | A | Outpatient | Urine | 2/24/06 | 64 | S83L, D87N | S80I | AMP, AMC, CTX, CAZ, ATM, FEP, TCC |
| 4 | I | A | Outpatient | Urine | 2/24/06 | 16 | S83L, D87N | S80I | AMP |
| 5 | IV | C | Medical | Urine | 4/5/07 | 64 | S83L, D87N | S80I | AMP, AMC, CTX, CAZ, ATM, FEP, TZP, TCC |
| 6 | V | C | Medical | Blood | 4/6/07 | 64 | S83L, D87N | S80I | AMP, AMC |
| 7 | VI | B | Medical | Urine | 1/15/07 | 128 | S83L, D87N | S80I | AMP |
| 8 | VII | A | Surgical | Trauma | 2/18/06 | 128 | S83L, D87N | S80I | AMP |
| 9 | VI | B | Medical | Ascitic fluid | 3/9/06 | 128 | S83L, D87N | S80I | AMP, AMC, TCC |
| 10 | VIII | A | Medical | Urine | 3/24/06 | 128 | S83L, D87N | S80I | AMP, AMC, TZP, TCC |
| 11 | IX | A | Medical | Pus | 5/31/06 | 32 | S83L, D87N | S80I | AMP |
a
Hospital A, AHEPA University Hospital, Thessaloniki; hospital B, Hippokration Hospital, Thessaloniki; and hospital C, University Hospital of Larissa, Larissa, Greece.
b
The susceptibility status was defined according to CLSI interpretative criteria (3).
c
Antibiotics: AMP, ampicillin; AMC, amoxicillin-clavulanate; ATM, aztreonam; CAZ, ceftazidime; CIP, ciprofloxacin; CTX, cefotaxime; FEP, cefepime; TCC, ticarcillin-clavulanate; and TZP, piperacillin-tazobactam.