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Experimental design for the study
| Route of administration | Racemic dose (mg/kg of body wt) | No. of rats
|
|
|---|---|---|---|
| Chiral analysis (1 to 3 plasma samples/rat) | Racemic analysis (8 to 16 plasma samples/rat) | ||
| Oral | 750 | 10 | 4 |
| 1,500 | 9 | 4 | |
| 2,000 | 7 | 4 | |
| 3,000 | 10 | 4 | |
| Intravenous | 375 | 5 | 4 |
| 1,000 | 5 | 3 | |
