TABLE 2.
Population pharmacokinetic parameter estimates for l- and d-eflornithine in the rat after intravenous administrationa
| Parameter | Value for l-eflornithine
|
R-eflornithine estimate (RSE) | Value for d-eflornithine
|
||
|---|---|---|---|---|---|
| Estimate (RSE) | IIV (RSE) | Estimate (RSE) | IIV (RSE) | ||
| CL (ml/min/kg of body wt) | 14.5 (8.5) | 14.9 (48) | 12.6 (5.9) | 18.2 (35) | |
| Vcentral (liters/kg of body wt) | 0.404 (13) | 0.401 (8.5) | |||
| Q (ml/min/kg of body wt) | 1.2 (11) | ||||
| Vperipheral (liters/kg of body wt) | 0.446 (15) | ||||
| Random residual variability (σ) (% coefficient of variation) | 19.9 (17) | ||||
a
R-eflornithine represents parameters that were set to be identical for l- and d-eflornithine. CL, clearance; Vcentral, central volume of distribution; Q, intercompartment clearance; IIV, interindividual variability; RSE, relative standard error [(standard error/mean) × 100]; σ, additive residual error.