TABLE 2.
Final parameter estimates for pharmacokinetic model for miltefosine
| Parameter | Estimate (relative SE [%]) | % Interindividual variability (relative SE [%])b |
|---|---|---|
| Absorption rate (ka) (h−1) | 0.36 (10.1) | 24.2 (63.3) |
| Clearance (CL/F) (liters/day) | 3.87 (5.3) | 23.2a (15.4) |
| Volume of central compartment (V2/F) (liters) | 39.6 (4.0) | 18.3a (25.0) |
| Intercompartmental clearance (Q/F) (liters/day) | 0.0375 (22.0) | NE |
| Volume of peripheral compartment (V3/F) (liters) | 1.65 (12.4) | NE |
| Residual variability (%) | 31.5 (6.4) | 23.2 (37.8) |
a
Interindividual variabilities in CL and V1 were correlated, with a correlation coefficient of 0.83 (relative SE, 23.1%).
b
NE, not estimated.