TABLE 2.
MICs of β-lactams and non-β-lactamsa
| Drug | MIC (μg/ml) against indicated isolate (genotype)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| K. pneumoniae clone A (blaOXA-48blaTEM-1blaSHV-12blaOXA-9) | K. pneumoniae clone B (blaOXA-48blaTEM-1blaCTX-M-15blaOXA-1) | E. coli J53(pAa) (blaCTX-M-15blaTEM-1blaOXA-1) | E. coli J53(pAb) or -(pBb) (blaOXA-48) | E. coli J53(pBa) (blaSHV-12blaTEM-1blaOXA-9) | E. coli J53 | K. pneumoniae isolate 11 (blaOXA-48blaTEM-1blaOXA-1) | K. pneumoniae isolate 21 (blaOXA-48blaTEM-1blaOXA-9) | |
| Amoxicillin | >512 | >512 | >512 | >512 | >512 | 1 | >512 | >512 |
| Amoxicillin + clavulanic acid | >512 | >512 | >513 | >512 | >512 | 1 | >512 | >512 |
| Ticarcillin | >512 | >512 | >514 | >512 | >512 | 4 | >512 | >512 |
| Ticarcillin + clavulanic acid | >512 | >512 | >515 | >512 | >512 | 4 | >512 | >512 |
| Piperacillin | >512 | >512 | >512 | >512 | >512 | 4 | >512 | >512 |
| Piperacillin + tazobactam | >512 | >512 | >4-8 | 64 | >4-8 | 4 | >512 | >512 |
| Cefotaxime | >512 | >512 | >32 | 0,5 | 4 | 0.5 | 4 | 4 |
| Ceftazidime | >512 | >512 | 128 | 1 | 64 | 1 | 2 | 2 |
| Cefepime | >512 | >512 | 4 | <0.5 | 0.5 | 0.125 | 4 | 4 |
| Aztreonam | >512 | >512 | 8 | <0.125 | 64 | 0.5 | 0.5 | 0.5 |
| Cefoxitin | 16-512 | 32->512 | 2-4 | 4-8 | 2-4 | 4 | 16 | >32 |
| Moxalactam | 16->512 | 16->512 | <0.5 | 2 | <0.5 | 1 | ||
| Imipenem | 4-32 | 4-16 | <1 | 0.5 | <1 | 2 | 8-16 | 8-16 |
| Meropenem | >32 | 6-32 | <1 | 0.12 | <1 | <1 | 16 | 16 |
| Ertapenem | >32 | >32 | <1 | 0.25 | <1 | <1 | >32 | >32 |
| Kanamycin | >256 | 128 | ||||||
| Tobramycin | >64 | >64 | ||||||
| Netilmicin | >128 | 3 | ||||||
| Amikacin | 16 | 2 | ||||||
| Gentamicin | >64 | 1 | ||||||
| Sulfamides | >256 | >256 | ||||||
| Trimethoprim | >32 | >32 | ||||||
| Tetracycline | >256 | >256 | ||||||
| Nalidixic acid | >64 | >64 | ||||||
| Norfloxacin | 8 | >256 | ||||||
| Ofloxacin | 2 | >64 | ||||||
| Ciprofloxacin | 1 | >128 | ||||||
a
MICs are for K. pneumoniae isolates of clones A and B, E. coli J53 harboring natural plasmids pAa or pAb from clone A, E. coli J53 harboring natural plasmids pBa or pBb from clone B, K. pneumoniae isolates 11 and 21, and E. coli J53, as indicated.