TABLE 2.
Amino acid changes in the GyrA QRDR of K. pneumoniae
| Susceptibility to ciprofloxacin | Amino acid change at position:
|
No. of isolates | Reference(s) and/or source | |
|---|---|---|---|---|
| 83 | 87 | |||
| Resistant | 9 | 2, 18; this study | ||
| Tyr | 15 | 1, 8, 11, 14, 20, 24 | ||
| Phe | 10 | 1, 2, 24 | ||
| Ile | 7 | 1, 2, 20; this study | ||
| Phe | Asn | 17 | 1, 2, 4, 5, 6, 11 | |
| Leu | Asn | 13 | 20; this study | |
| Tyr | Asn | 10 | 20, 24 | |
| Phe | Tyr | 4 | 1, 11 | |
| Phe | Ala | 3 | 4, 5, 6 | |
| Phe | Gly | 3 | 4, 5, 24 | |
| Tyr | Tyr | 2 | 1, 2 | |
| Ile | Asn | 1 | 20 | |
| Intermediate resistant | 1 | 18 | ||
| Tyr | 14 | 1, 4, 5, 8, 20 | ||
| Phe | 5 | 1, 4, 5 | ||
| Ile | 1 | This study | ||
| Gly | 3 | 4, 5; this study | ||
| Phe | Gly | 1 | 4, 5 | |
| Susceptible | 37 | 4, 5,1, 4, 5, 11, 14, 18, 25; this study | ||
| Tyr | 17 | 4, 5,4, 5, 8, 11, 20; this study | ||
| Phe | 7 | 4, 5,4, 5, 11, 18, 24 | ||
| Leu | 1 | This study | ||
| Ile | 1 | This study | ||
| Thr | 1 | This study | ||
| Gly | 1 | 4, 5 | ||
| Asn | 1 | This study | ||
| Total | 185 | |||