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. 2008 May 30;190(15):5382–5393. doi: 10.1128/JB.00307-08

TABLE 3.

Summary of transcriptome comparison of S. pneumoniae strain D39 grown in GM17 and in GM17 with addition of 0.25 mM Zn2+

TIGR4 locus tag Function (TIGR annotation) Ratioa
SP0202 Anaerobic ribonucleoside triphosphate reductase NrdD 2.5
SP0204 Predicted acetyltransferase, GNAT family 2.4
SP0205 Anaerobic ribonucleoside triphosphate reductase activating protein NrdG 1.8b
SP0206 Hypothetical protein; predicted uridine kinase 1.8b
SP0207 Hypothetical protein; predicted uridine kinase 2.2
SP0303 6-Phospho-β-glucosidase BglA −7.6
SP0305 Phosphotransferase system cellobiose-specific component IIB −4.1
SP0306 Putative transcriptional regulator; possible antiterminator BglG −14.8
SP0307 Phosphotransferase system, IIA component −6.3b
SP0308 Phosphotransferase system cellobiose-specific component IIA −3.0
SP0309 Hypothetical protein −7.6
SP0310 Phosphotransferase system cellobiose-specific component IIC −6.0
SP0338 Putative ATP-dependent clp protease, ATP binding subunit ClpL −2.0
SP0515 Heat-inducible transcription repressor HrcA −2.0
SP0516 Heat shock protein GrpE −1.6
SP0517 Chaperone protein DnaK (heat shock protein 70) −1.4
SP0518 Hypothetical protein −2.1
SP0519 Chaperone protein DnaJ −1.4
SP0640 Hypothetical protein 1.5b
SP0641 Cell wall-associated serine proteinase precursor PrtA 2.7
SP0645 Putative phosphotransferase system IIA component 2.8
SP0646 Phosphotransferase system, IIB component, putative 2.4
SP0879 Hypothetical protein −2.1
SP1648 Manganese (and/or zinc) ABC transporter, ATP binding protein PsaB 2.3
SP1649c Manganese (and/or zinc) ABC transporter, permease protein PsaC 2.6
SP1762 Hypothetical protein 2.7
SP1855 Alcohol dehydrogenase, zinc-containing AdhB 1.7
SP1856 Transcriptional regulator, MerR family 2.0b
SP1857 Cation efflux system protein CzcD 7.2
SP1935 Hypothetical protein 2.8
SP2136 Choline binding protein; surface protein PcpA 8.5
a

Ratios of >2.0 or <−2.0 (wild-type D39 compared to wild-type D39 plus 0.25 mM Zn2+) are shown; in some cases neighboring genes with lower fold changes are also indicated.

b

Ratio with a false discovery rate of >0.01 but <0.1.

c

For SP1650 (psaA), the number of observations (replicates) was too low and hence no significance was obtained.

HHS Vulnerability Disclosure