TABLE 3.
Summary of transcriptome comparison of S. pneumoniae strain D39 grown in GM17 and in GM17 with addition of 0.25 mM Zn2+
| TIGR4 locus tag | Function (TIGR annotation) | Ratioa |
|---|---|---|
| SP0202 | Anaerobic ribonucleoside triphosphate reductase NrdD | 2.5 |
| SP0204 | Predicted acetyltransferase, GNAT family | 2.4 |
| SP0205 | Anaerobic ribonucleoside triphosphate reductase activating protein NrdG | 1.8b |
| SP0206 | Hypothetical protein; predicted uridine kinase | 1.8b |
| SP0207 | Hypothetical protein; predicted uridine kinase | 2.2 |
| SP0303 | 6-Phospho-β-glucosidase BglA | −7.6 |
| SP0305 | Phosphotransferase system cellobiose-specific component IIB | −4.1 |
| SP0306 | Putative transcriptional regulator; possible antiterminator BglG | −14.8 |
| SP0307 | Phosphotransferase system, IIA component | −6.3b |
| SP0308 | Phosphotransferase system cellobiose-specific component IIA | −3.0 |
| SP0309 | Hypothetical protein | −7.6 |
| SP0310 | Phosphotransferase system cellobiose-specific component IIC | −6.0 |
| SP0338 | Putative ATP-dependent clp protease, ATP binding subunit ClpL | −2.0 |
| SP0515 | Heat-inducible transcription repressor HrcA | −2.0 |
| SP0516 | Heat shock protein GrpE | −1.6 |
| SP0517 | Chaperone protein DnaK (heat shock protein 70) | −1.4 |
| SP0518 | Hypothetical protein | −2.1 |
| SP0519 | Chaperone protein DnaJ | −1.4 |
| SP0640 | Hypothetical protein | 1.5b |
| SP0641 | Cell wall-associated serine proteinase precursor PrtA | 2.7 |
| SP0645 | Putative phosphotransferase system IIA component | 2.8 |
| SP0646 | Phosphotransferase system, IIB component, putative | 2.4 |
| SP0879 | Hypothetical protein | −2.1 |
| SP1648 | Manganese (and/or zinc) ABC transporter, ATP binding protein PsaB | 2.3 |
| SP1649c | Manganese (and/or zinc) ABC transporter, permease protein PsaC | 2.6 |
| SP1762 | Hypothetical protein | 2.7 |
| SP1855 | Alcohol dehydrogenase, zinc-containing AdhB | 1.7 |
| SP1856 | Transcriptional regulator, MerR family | 2.0b |
| SP1857 | Cation efflux system protein CzcD | 7.2 |
| SP1935 | Hypothetical protein | 2.8 |
| SP2136 | Choline binding protein; surface protein PcpA | 8.5 |
a
Ratios of >2.0 or <−2.0 (wild-type D39 compared to wild-type D39 plus 0.25 mM Zn2+) are shown; in some cases neighboring genes with lower fold changes are also indicated.
b
Ratio with a false discovery rate of >0.01 but <0.1.
c
For SP1650 (psaA), the number of observations (replicates) was too low and hence no significance was obtained.