Table 2.

IC₅₀ Values of Antipsychotics for Ionic Currents/Channels

Compound	Model system	Potassium channels/currents				Calcium channels/current	Sodium channels/currents INa	References
		KV/delayed rectifier IKr	Transient outward Ito	Inward rectifier IK1	HERG	ICaL
Chlorpromazine	CHO				1.47 μM			157
Clozapine	HEK-293		>50 μM		320 nM		29 μM	148
Droperidol	Ventricular myocytes HEK-293	28 nM			32.2 μM			145
Fluspirilene	Xenopus oocytes				2.34 μM			150
Haloperidol	PC12 cells					20 μM		164
	Ventricular myocytes						5 μM	81
	HEK-293		>10 μM	>100 μM	26.8 nM		14.4 μM	148
					20 nM			165
	Xenopus oocytes				1.36 μM			150
	Xenopus oocytes				1.0 μM			146
Olanzapine	HEK-293		>100 μM	>100 μM	731 nM		>100 μM	148
	CHO				6013 nM			147
Pimozide	HEK-293		>100 μM	>100 μM	54.6 nM		21.9 μM	148
	Xenopus oocytes				1.74 μM			150
	CHO				18 nM			154
Quetiapine	CHO				5765 nM			147
Risperidone	canine ventricular myocytes				0.92 μM			151
	HEK-293		>100 μM	>100 μM	148 nM		>50 μM	148
	CHO				167 nM			147
	CHO				261 nM			155
Sertindole	HEK-293		>10 μM	>10 μM	14 nM		>10 μM	148
	HEK-293			21 μM	14.7 nM			153
	CHO				3 nM			147
Thioridazine	Ventricular myocytes	1.25 μM						149
	tsA201
	CHO				1.25 μM
	CHO				1.07 μM			158
	HEK-293				91 nM			147
			27 μM		33.2 nM		7 μM	148
Ziprasidone	HEK-293		>10 μM	> 10 μM	125 nM		>10 μM	148
	CHO				169 nM			147

CHO =Chinese hamster ovary cells; PC12 cells=rat pheochromocytoma cells; HEK-293= Human embryonic kidney cells.