TABLE 1.
Systemic disease and virus titers in tissues of SA11-infected IFNαγR KO and wild-type mice
| Mice | % with Diseasea | Days p.i. | Virus titer (PFU/g)b
|
||
|---|---|---|---|---|---|
| Intestine | Liver | Bile duct | |||
| IFNαγR KO | 50 | 5 | 3,234* (300-67,000) | 2,965 (670-1,400) | 66,916 (5,700-1,800,000) |
| 8 | 86* (<300-10,000) | 539* (<300-130,000) | 1,656* (<200-56,000) | ||
| Wild type | 0 | 5 | 3 (<300-300) | 152 (<300-50,000) | 389 (<300-330,000) |
| 8 | <300 | <300 | <300 | ||
a
Maximum rate of disease observed after infection. n = 8 and 7 for IFNαγR KO and wild-type mice, respectively. The disease was less severe than RRV infection.
b
Geometric mean virus titer, with minimum and maximum titers in parentheses. Number of mice in each group was between 6 and 9. *, P < 0.05 by Mann-Whitney test between IFNαγR KO and wild-type mice at the same time point.