FIG. 2.

Induction of cytokine/chemokine transcription. Proinflammatory cytokine/chemokine transcription was measured following intravenous delivery of 2 × 10¹² viral genomes of rAAV6-CMV-hAP or 10¹¹ viral particles of Ad5-CMV-GFP to C57/BL6 mice. Induction of IL-1β, IL-6, TNF-α, MCP-1, or IP-10 gene transcription is shown as the change in cycle threshold (ΔC_T) for qPCR versus that for PBS-injected control animals. For each cytokine/chemokine, time point, and vector, the average of the test ΔC_T values was calculated and divided by the ΔC_T value for PBS-injected animals. P values are for test groups versus PBS-injected animals.