Figure 2.

Comparison of proximal mChr6 gene expression in wild-type and Dnmt3l^−/+ embryo and trophoblast giant cells. (A) Expression of genes in trophoblast giant cells isolated from both Dnmt3l^−/+ and wild-type placenta. The paternally expressed genes show an increase in expression, while the maternally expressed genes all show a decrease. (B) Increased expression in E8.5 Dnmt3l^−/+ embryos compared with wild type for the paternally expressed genes Peg10 and Sgce. The expression of Asb4 exhibits a decrease in expression in Dnmt3l^−/+ embryos. All expression values are presented as a ratio to the housekeeping gene Gapdh and are normalized to wild-type values.