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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Immunol. 2008 Jul 1;181(1):309–319. doi: 10.4049/jimmunol.181.1.309

Figure 2.

Figure 2

AHR in γδ T cell-deficient recipients reconstituted with CD8-selected Vγ4+ cells, after systemic sensitization and airway challenge with OVA (2ip3N protocol). (a,b) Lung resistance (RL) and dynamic compliance (Cdyn) as percent changes from saline controls in relation to increasing doses of aerosolized MCh. Recipients: B6.TCR-Vγ4/6−/− mice; donors: 2ip3N-treated B6.TCR-β−/− or C57BL/6 mice. Treatments: none (NT), systemic sensitization and airway challenge (2ip3N), 2ip3N plus selected purified Vγ4+ /CD8β+ or − or Vγ4+ /CD8α+ or − cells from the donors. (a) Recipients untreated or after 2ip3N or 2ip3N plus selected Vγ4+ /CD8β+ or − cells from B6.TCR-β−/− donors (* non-treated compared with 2ip3N); (b) Recipients untreated or after 2ip3N or 2ip3N plus selected Vγ4+/CD8α+ or − cells from C57BL/6 donors (* non-treated compared with 2ip3N, # 2ip3N compared with 2ip3N plus CD8α+ Vγ4 cells, + 2ip3N compared with 2ip3N plus CD8α− Vγ4 cells).