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. 2008 Aug;22(8):3010–3023. doi: 10.1096/fj.07-100966

Figure 6.

Figure 6.

Ang1–256 monomer reduces cardiac hypertrophy in vivo. Ang1–256/pcDNA (ang1–256) or pcDNA (control) was retroorbitally injected into C57 mice. On day 2, mice were given PE or saline via pumps (n=4/group; studies done in duplicate). A) At day 6, PE increased LV/tibia ratios, and ang1–256 monomer blunted PE-induced increases in LV/tibia ratios. *P = 0.009; **P=0.02. B–G) RT-PCR analysis shows PE up-regulated mRNA levels of ANP (B), BNP (C), collagen III (D), skeletal actin (E), and (F) βMHC, but not SMA (G). Ang1–256 monomer reduced ANP, BNP, collagen III, skeletal actin, βMHC, and SMA mRNA levels in the absence or presence of PE. *P ≤ 0.03; **P ≤ 0.02; ***P = 0.006.