Figure 3.

Exercise-induced MnSOD up-regulation attenuates IR-induced apoptosis. A) Texas Red-labeled laminin, DAPI-labeled nuclei, and FITC-labeled TUNEL-positive nuclei; arrows indicate TUNEL-positive myonuclei. B) Representative sections analyzed immunohistochemically for activated caspase-3. C) Caspase-3 cleaves αII-spectrin to yield a 120-kDa band that was normalized to total αII-spectrin for that sample and expressed as a percentage of C (group not shown). Error bars are mean ± se. *P < 0.05 vs. C-IR and T-AS-IR groups.