Figure 2.

Inhibition of CD73 by APCP increases injury. Injury was measured after WT mice were treated with APCP (40 mg/kg/h, i.a.) or sterile saline and subjected to 15 min of ischemia, followed by 3 h reperfusion. Injury was measured for the following parameters: Intestinal MPO (A), lung MPO (B), AST (C), IL-6 (D), IL-1 (E), H&E staining of jejunum sections (×200) (F), and quantification of ischemic injury (median±range; n=3–5 mice/group) (G). All other results are expressed as mean ± se; 8–12 mice/group.