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Treatment with NECA, a nonspecific adenosine receptor agonist, decreases IR injury. Injury was measured after WT or cd73−/− mice were treated with NECA (0.1 mg/kg, i.p., plus 0.1 mg/kg, s.c.) or sterile saline and subjected to 15 min of ischemia, followed by 3 h of reperfusion. Injury was measured for the following parameters: intestinal MPO (A), lung MPO (B), ALT (C), IL-6 (D), and IL-1 (E). All results are expressed as mean ± se; 4–8 mice/group.
