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Model of interareal communication via a corticothalamocortical pathway. In this model, driver projections (red, thick lines) represent the major information route and, in the example shown, the route from the first-order to the higher-order cortical area involves a corticothalamocortical pathway emanating from layer 5 of the first-order area. Also shown are modulatory pathways (green lines) from layer 6 both to layer 4 and to thalamus.
