Table 1.

Time spent ± SEM in the open and closed arms of the elevated plus maze and closed arm entries ± SEM by rats injected intraperitoneally with one of two doses (0.0 or 3.0 g/kg) of 10% w/v ethanol

Ethanol dose	Gabapentin dose (mg/kg)	n	Time spent in open arms (s)	Time spent in closed arms (s)	Closed arm entries
0.0 g/kg	0	8	35.70 ± 12.02	101.30 ± 18.26	26.00 ± 3.78
	30	7	42.60 ± 9.51	112.90 ± 7.61	23.71 ± 1.95
	60	8	54.75 ± 12.77	126.38 ± 5.53	23.13 ± 3.07
	120	8	29.00 ± 12.47	148.75 ± 6.44	19.88 ± 8.46
3.0 g/kg*	0	8	14.10 ± 6.39	189.00 ± 20.39	19.75 ± 3.85
	30	7	24.30 ± 10.97	148.80 ± 34.33	20.14 ± 2.68
	60	8	31.38 ± 11.45	164.63 ± 25.46	9.63 ± 2.35
	120	8	43.00 ± 16.54	130.00 ± 27.53	13.25 ± 4.86

The plus-maze test was administered 10 h after ethanol injection, and 30 min after intraperitoneal injection with one of four gabapentin doses (0, 30, 60, or 120 mg/kg). The plus-maze test lasted 300 s in total duration.

*p < 0.05 significant main effect of ethanol on closed arm entries.