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Hyperglycemia decreases Sp1 protein expression in vivo and in vitro. A: HG treatment for 24 h downregulates Sp1 protein expression in rat vascular ECs. n = 4 experiments in ECs treated with NG and HG, respectively. *P < 0.05 vs. NG-treated cells. Data are expressed as means ± SE. B: coronary ECs isolated from diabetic mice (D, n = 6) exhibits significantly lower Sp1 protein than ECs from control mice (C, n = 7). *P < 0.05 vs. control. Data are expressed as means ± SE.
