Table 1.
Susceptibility and resistance of transgenic mice to BSE prions
| Inoculum | Recipient | Transgene expression | Incubation time, days ± SE | n/no |
|---|---|---|---|---|
| Mice deficient for PrP (Prnp0/0) | ||||
| BSE(PG31/90) | Tg(BoPrP)4125 | 8–16 × | 234 ± 8 | 10/10 |
| BSE(PG31/90) | Tg(BoPrP)4092 | 4–8 × | 319 ± 15 | 8/8 |
| BSE(GJ248/85) | Tg(BoPrP)4125 | 8–16 × | 281 ± 19 | 10/10 |
| BSE(GJ248/85) | Tg(BoPrP)4092 | 4–8 × | 343 ± 18 | 8/8 |
| BSE(GJ248/85) | Tg(MBo2M)14586 | 8–16 × | >600 | 0/15 |
| BSE(PG31/90) | Tg(MBo2M)14586 | 8–16 × | >600 | 0/13 |
| BSE(574C) | Tg(MBo2M)14586 | 8–16 × | >600 | 0/13 |
| Mice expressing MoPrP-A | ||||
| BSE(GJ248/85) | FVB | 0 | 628 ± 47 | 2/3 |
| BSE(PG31/90) | FVB | 0 | 448 ± 29 | 2/2 |
| BSE(574C) | FVB | 0 | 525 ± 34 | 4/4 |
| BSE(PG31/90) | Tg(MoPrP-A)4053 | 8–16 × | >310 | 4/10 |
| BSE(GJ248/85) | Tg(MoPrP-A)4053 | 8–16 × | 322 ± 6 | 8/9 |
| BSE(PG31/90) | Tg(BoPrP)333 | 0* | 426 ± 11 | 8/8 |
| BSE(PG31/90) | Tg(BoPrP)833 | 0* | 395 ± 22 | 9/9 |
| BSE → Tg(BoPrP)333 | CD-1 | 0 | 155 ± 3 | 16/16 |
*
No BoPrP was detected by Western immunoblotting.