Figure 4.

Anti-rabCD14 protects from renal injury induced by three sequential i.v. injections of LPS (5 μg/kg at t = 0, 5, and 24 hr). The upper panels show representative lesions from an untreated rabbit (that received LPS but no antibody: LPS/0). The hemisectioned kidney shows advanced cortical necrosis, and the periodic acid/Schiff reagent-stained histologic section shows marked glomerular fibrin deposition and tubular necrosis. The lower panels are representative of the anti-rabCD14-treated groups (LPS:αCD14) showing a hemisectioned kidney and histologic section from a rabbit that received LPS injections and antibody delayed treatment at t = 4 and 23 hr. Kidneys from rabbits that received anti-rabCD14 antibody (either prophylactic or delayed treatment) were essentially normal, with changes limited to mild edema and occasional inflammatory infiltrates (X400).