Table 1.
Anti-rabCD14
|
Anti-rabTNF
|
Controls
|
||||
---|---|---|---|---|---|---|
Prophylactic treatment | Delayed treatment | Prophylactic treatment | Delayed treatment | LPS ± control mAb | No LPS | |
48-hr survival | 100%* (13/13) | 100%* (26/26) | 100%* (11/11) | 67% (8/12) | 68% (21/31) | 100%* (15/15) |
Renal cortical necrosis | 0%† (0/13) | 0%† (0/26) | 64% (7/11) | 58% (7/12) | 84% (26/31) | 0%† (0/15) |
Pulmonary injury | 0%† (0/13) | 0%† (0/26) | 27% (3/11) | 33% (4/12) | 61% (19/31) | 0%† (0/15) |
P < 0.05 compared with untreated group (LPS ± control mAb) using Fisher Exact test.
P < 0.001 compared with untreated group (LPS ± control mAb) using Fisher Exact test.