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. 2008 Apr 23;295(1):F290–F294. doi: 10.1152/ajprenal.00072.2008

Fig. 2.

Fig. 2.

Trafficking pattern of AQP2 in cells stably expressing AQP2-wild-type, AQP2-S256A, AQP2-S256D, AQP2-S261A, and AQP2-S261D in response to vasopressin (VP). In cells expressing wild-type AQP2, AQP2 is present in the perinuclear region under basal conditions and accumulated on the plasma membrane upon VP treatment (A and F), and AQP2-S256A remains perinuclear with or without VP stimulation (B and G). AQP2-S256D is mainly located on the plasma membrane under both basal and stimulated conditions (C and H), while AQP2-S261A and AQP2-S261D respond to VP by accumulating on the plasma membrane, similar to wild-type AQP2 (D, E, I, and J).